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04 Jun

When asked what the study tells us about the chance of someone with an undetectable viral load transmitting HIV, presenter Alison Rodger said: "Our best estimate is it's zero." The previous study, HPTN 052, established in 2011 that the efficacy of antiretroviral therapy at reducing HIV transmission from the HIV-positive partner to the HIV-negative one was at least 96% in heterosexual couples, but had too few gay couples in it to establish if the same applied to them (or rather to anal sex).

The PARTNER study was designed to remedy this gap in knowledge.

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In order to be in the study, couples have to be having sex without condoms at least some of the time.

The HIV-negative partner cannot be using post-exposure or pre-exposure prophylaxis (PEP or Pr EP) and the HIV-positive partner has to be on ART, with the most recent viral load below 200 copies/ml.

This is different from HPTN052, which measured the efficacy of the HIV positive partner starting therapy (versus partners who did not).

The second large study to look at whether people with HIV become non-infectious if they are on antiretroviral therapy (ART) has found no cases where someone with a viral load under 200 copies/ml transmitted HIV, either by anal or vaginal sex.

Statistical analysis shows that the maximum likely chance of transmission via anal sex from someone on successful HIV treatment was 1% a year for any anal sex and 4% for anal sex with ejaculation where the HIV-negative partner was receptive; but the true likelihood is probably much nearer to zero than this.